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Enoxaparin sodium injection Indications and Usage for Enoxaparin Sodium Injection Prophylaxis of Deep Vein Thrombosis Enoxaparin Sodium Injection is indicated for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE): in patients undergoing abdominal surgery who are at risk for thromboembolic complications [see Clinical Studies 14.1 in patients undergoing hip replacement surgery, during and following hospitalization. in patients undergoing knee replacement surgery. in medical patients who are at ris