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Argireline Anti-wrinkle EssenceArgireline is a hexapeptide (a chain of 6 amino acids) attached to the acetic acid residue. It is believed to work by inhibiting the release of neurotransmitters. When applied to the skin, Argireline supposedly relaxes facial tension leading to the reduction in facial lines and wrinkles with regular use. This remotely resembles the effect of Botox, which reduces facial tension and movement by paralyzing facial muscles. Note that Argireline is unrelated in its physiologic effect and mechanism of action to other bioactive skin peptides, such aspalmitoyl pantapeptide.