Indications: The treatment of infections caused by susceptible organisms.

Contra-indications: Co-trimoxazole is contra-indicated in patients with a history of sensitivity to it or to the sulphonamides. Trimoxazole should not be given to patients with megaloblastic anaemia, and should be avoided in those patients who may have megaloblastic bone-marrow changes or folic acid deficiency and also in patients receiving anticonvulsant medicines.

Co-trimaxazole is contra-indicated in patients with impaired hepatic function and in patients with severe renal insufficiency.

Co-trimoxazole is contra-indicated during pregnancy and should not be given to women prior to delivery (because of the danger of producing kernicterus in the infant), nor to nursing mothers. It is also contra-indicated in patients with porphyria.

Precautions: Erythema multiforme, toxic epidermal necrolysis and allergic vasculitis may occur.

Dosage and Administration:Adult and children over 12 years: Two tablets twice a day, mornin and evening, after meals.

Maximum dose (for severe cases): Three tablets twice a day.

Children from 6 to 12 years: One tablet twice a day, morning and evening, after meals.

The dosage must be reduced in patients with renal insufficiency and the preparation should not be administered if the creatinine clearance rate is less than 15 ml/minute.

Frequent haematological investigations are required during prolonged therapy.

Storage instructions:Store below 25 degrees celsius. Protect from moisture. Keep out of reach of children.

Validity: Three Years